APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
SK-N-SH Cell Lysate(GTX23956)
Product Note
At least three isoforms of FGFR3 are known to exist; this antibody will detect all three.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
FGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3.The immunogen is located within amino acids 630 - 680 of FGFR3.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
fibroblast growth factor receptor 3 , ACH , CD333 , CEK2 , HSFGFR3EX , JTK4
Cellular Localization
Cytoplasmic vesicle,Endoplasmic reticulum
Background
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
Database
Research Area
DATA IMAGES
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GTX31549 IHC-P Image
IHC-P analysis of rat brain tissue using GTX31549 FGFR3 antibody.
Working concentration : 2.5 μg/ml
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GTX31549 IHC-P Image
IHC-P analysis of rat brain tissue using GTX31549 FGFR3 antibody.
Working concentration : 20 μg/ml
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GTX31549 WB Image
WB analysis of SK-N-SH cell lysate using GTX31549 FGFR3 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml
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REFERENCE
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REVIEW
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